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  1. Most common malignancy of childhood; second is brain tumor.
  2. The frequency of leukemia increases with
    1. Fanconi’s anemia
    2. Down syndrome
    3. Bloom’s syndrome
    4. Klinefelter’s syndrome.
    5. Wiskott Aldrich syndrome and ataxia telangiectasia.
    6. Radiation exposure increases the risk of all leukemias except CLL and hairy cell.
  3. Incidence of leukemia is 13 /Lac population.

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