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Dermatology

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Cutaneous Malignancies

Question
4 out of 28
 

Marker for langerhan’s cell histiocytosis (LQ)


A CD-1a
B Cd-57

C Cd-34
D Cd-54

Ans. A
CD-1a

(Langerhans' Cell Histiocytosi)

1). In the past these disorders were referred to as histio­cytosis X and subdivided into three catagories: Let­teer-Siwe syndrome, Hand-schuller-Christian disease, and eosinophilic granuloma.

2). These three conditions are now believed to represent different expressions of the same basic disorder. The proliferating cell in all forms is of the marrow origin that is normally found in the epidermis.

3). These cells, believed to be a part of the mononuclear phagocyte system, are HLA-DR positive and express the CDl antigen.

4). They have ab1indant, often vacuolated cytoplasm, with vesic­ular oval or indented nuclei. Characteristic is the presence of HX bodies (Birbeck granules) in the cyto­plasm.

5). Under the electron microscope these are seen to have a pelltalaminar, rod-like, tubular structure, with characteristic periodicity and sometimes a dilated terminal end (tennis racket appearance).

Cutaneous Malignancies Flashcard List

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