Marker of bone formation are all except (AIIMS NOV.2011)
(Ref: 23rd edition Ganong's Page-301)
I. Biochemical markers of bone formation are
a. serum alkaline phosphatase,
b. osteocalcin, and
c. the carboxy-terminal extension peptide of pro-collagen 1.
II. Osteocalcin is secreted solely by osteoblasts and thought to play a role in the body's metabolic regulation and is pro-osteoblastic, or bone-building, by nature.It is also implicated in bone mineralization and calcium ion homeostasis.
III. Procollagen 1 Carboxyterminal Peptide (P1CP) is the precursor of collagen, synthesized in osteoblasts and fibroblasts and subsequently converted to form collagen by procollagen peptidase.