Medical and Surgical Complications in Pregnancy
Maximum incidences of congenital malformation are seen during pregnancy with infection of: (LQ)
1. Rubella can cause severe outcomes in the fetus, including fetal death and premature delivery, if the mother is infected during early pregnancy.
2. A variety of congenital defects are caused by rubella, viz. cataracts, cardiac abnormalities, deafness, and mental retardation. Fetal abnormalities are greatest when maternal rubella occurs during the 1st trimester, with 80% of children affected; the percentage falls to about 25% when infection occurs at the end of the 2nd trimester.
3. Congenital infection can be diagnosed prenatally by detecting rubella IgM antibody in fetal blood obtained under USG guidance.