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Pathology

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Neoplasia

Question
5 out of 25
 

Maximum increase in alpha-fetoprotein increased is seen with: (AIIMS May 2014)



A Hepato-cellular-carcinoma
B Benign-mature teratoma

C Chorio-carcinoma
D Teratoma

Ans. A i.e. Hepato-cellular-carcinoma

AFP is glycoprotein synthesized normally early in fetal life by yolk sac, fetal liver and fetal GIT.

Cause of rise in AFP is

Neoplastic causes

Nonneoplastic causes

- Primary carcinoma of liver

- Toxic liver injury

- Hepatoblastoma

- Hepatitis

- Non seminomatous germ cell of testis (not in seminoma)

- Pregnancy (especially with fetal distress or death)

- Ovarian germ cell tumor

- Cirrhosis

- Carcinoma of colon, Lung, Pancreas, Breast, Renal and Gastric

"AFP levels > 500 μg/L are found in about 70-80% of patients with HCC. Lower levels may be found in patients with large metastases from gastric or colonic tumors and in some patients with acute or chronic hepatitis. High levels of serum AFP (> 500-1000μg/L) in adult without liver disease and without an obvious GIT tumor strongly suggest HCC.

Neoplasia Flashcard List

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