Oncology and Fibroids
Mc agent for cervical carcinoma.... (AIPG 2010)
1. Risk Factors for Ca Cervix
a. Young age at first intercourse (< 16 years)
b. Multiple sexual partners
c. Cigarette smoking
d. High parity
e. Low socioeconomic status
f. HPV infection
g. Immuno suppression
2. HPV-16 is the most common HPV seen in invasive cancer and CIN 2/3
3. CIN:- CIN is a histopathological condition where part or whole of the cervical squamous epithelium is replaced by cells showing varying degrees of atypia.
4. DYPLASIA:- Dysplasia represents a change causing alteration and disorderly arrangement of the cells of stratified squamous epithelium.
5. CIN I (Mild Dysplasia):- The dysplastic cells are confined to the lower one third of epithelial layer. It is seen in inflammatory conditions e.g. Trichomoniasis. Treatment is antibiotics (Metronidazole 200 mg 1 TDS X 7 days.)
6. CIN II (Moderate Dysplasia):- The lower 75% of the epithelial layer is undifferentiated.
7. CN III (Severe Dysplasia):- The entire thickness of epithelium is replaced by anaplastic cells. Surface cornification and stratification is lost. The basement membrane remains intact and therefore there is no stromal infiltration. It is not reversible and may progress to invasive cancer. About 10-30% cases ultimately progress to cancer in 5-10 years’ time. The CIN III is also called CARCINOMA in site or CIS.