Mechanism of acion of theophylline in bronchial Asthma is (AI 2010)
|A||Phosphodiesterase 4 inhibition|
|D||Inhibition of mucociliary clearance|
Theophylline is used in bronchial asthma. Its mechanism of action is:
Inhibition of phosphodiesterases particularly PDE-4. Antagonism of adenosine receptors.
Enhancement of histone deacetylation. Acetylation of histone is required for activation of inflammatory gene tran- scription. By inhibiting this process, low-dose theophylline may restore responsiveness to corticosteroids.