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Pharmacology

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Respiratory Systems

Question
32 out of 47
 

Mechanism of acion of theophylline in bronchial Asthma is (AI 2010)



A Phosphodiesterase 4 inhibition

B Beta2 agonism

C Anticholinergic action

D Inhibition of mucociliary clearance

Ans. A Phosphodiesterase 4 inhibition (Ref: Katzung 11th/345)

Theophylline is used in bronchial asthma. Its mechanism of action is:

Inhibition of phosphodiesterases particularly PDE-4. Antagonism of adenosine receptors.

Enhancement of histone deacetylation. Acetylation of histone is required for activation of inflammatory gene tran- scription. By inhibiting this process, low-dose theophylline may restore responsiveness to corticosteroids.

Respiratory Systems Flashcard List

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