Mechanism of multi drug resistance is mainly due to:
|A||Acquired through mutation in the DNA|
|B||Efflux of drug by P glycoprotein|
|C||Change in DNA polymerase|
|D||Change in protein synthesis|
According to KDT –
I. The multi-drug resistance is seen as a consequence of acquisition of R-plasmid through conjugation.
II. This contains chromosomal or extra-chromosomal DNA.
III. Efflux of p proteins is effective against few drugs while only selected class of protein synthesis inhibitors will be affected by change in protein synthesis.
IV. Change in DNA polymerase will affect very few drugs.
V. Thus according to the clue from the reference; option A would be the best one.