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Clinical Stages of Asthma

Stage Po2 PCO2 pH FEV1 (%) predicted
Mild respiratory alkalosis
Respiratory alkalosis
Danger zone
Respiratory acidosis
Normal




Normal


Normal
65-80
50-64
35-49
<35
 
Step Therapy of Chronic Asthma During Pregnancy
 
 Severity Step Therapy
Mild intermittent
 
Mild persistent
 
 
 
 
Moderate persistent
 
 
 
Severe persistent
Inhaled β-agonists-salbutamol, metaproterenol, isoproterenol, salmeterol
 
Inhaled β-agonists-as above
Inhaled cromolyn - continue if taking prior to pregnancy with good response
Substitute inhaled corticosteroids if no response - beclomethasone, budesonide, triamcinolone
 
Inhaled β-agonists as above
Inhaled corticosteroids as above, add oral theophylline and/ or inhaled salmeterol if inhaled medium-dose steroids inadequate
 
For moderate, as above plus oral corticosteroids-burst for active symptoms, alternate day or daily if necessary

PCF2 alpha is absolutely contraindicated, PGE1 or PGE2 can be used with caution




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