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Medicine

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Hematology

Question
12 out of 16
 

Megaloblastic anemia due to folic acid deficiency is commonly due to: (AIPG 2011)



A Inadequate dietary intake

B Defective intestinal absorption

C Absence of folic acid binding protein in serum

D Absence of glutamic acid in the intestine

Ans. A

Inadequate dietary intake

Folic acid deficiency

Causes of Folate Deficiency (Ref. Hari- 18th ed., Pg. 869, table 105.5)

1. Dietary cause

2. Malabsorption (alcoholism, celiac and tropical sprue, Crohn’s disease, scleredema, hypothyroidism)

3. Increased demand of folate – pregnancy, cell proliferation as in hemolysis, neoplasia, hyperthyroidism, ineffective erythropoiesis (pernicious anemia, sideroblastic anemia). Q

4. Drugs (phenytoin, methotrexate, trimethoprim, pyrimethamine, alcohol). Q

Metabolism of Folate

Total body storage capacity is up to 5 mg (3 – 4 months supply).

Hematology Flashcard List

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