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Medicine

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Hematology

Question
14 out of 16
 

Megaloblastic anemia should be treated with both folic acid vitamin B12 because: (AIPG 2009)



A Folic acid alone causes improvement of hematologic symptoms but worsening of neurological symptoms

B It is a Co factor

C It is enzyme

D None of the above

Ans. A

Folic acid alone causes improvement of hematologic symptoms but worsening of neurological symptoms

Extra Edge: If folic acid alone is given in macrocytic anemia it can improve blood picture but it will precipitate CNS features which occur due to B12 deficiency. So in macrocytic anemia both folic acid and B12 should be given together. (AIIMS May 2010)

Management

1. In B12 deficiency, hydroxocobalamin 1000 mg twice during the first week,

2. In folate deficiency 5 mg of folic acid/day orally is given.

Folate supplements 350 mg daily is given for all pregnant women.

Hematology Flashcard List

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