Loading....
Coupon Accepted Successfully!

Pharmacology

Open Flashcards

GIT

Question
43 out of 53
 

Metoc1opramide (LQ)



A Inhibit cholinergic smooth muscle stimulation in the gastrointestinal tract

B Decrease lower esophageal sphincter pressure

C Stimulate D2 receptor

D Enhance colonic motility

Ans. D Enhances colonic motility (Ref. : Katzung l0th/1021; KDT 6th/643)

Metoclopramide is a D2 receptor antagonist that increases cholinergic activity by inhibiting pre-synpatic D1receptors in GIT (D, receptor stimulation inhibits the release of ACh).

• it increase LES tone that is also responsible for anti-emetic action.

• It does not significantly increase colonic motility.

• But out of the four options, this is the best answer, because although not significantly but it can increase colonic motility, whereas other options are definitely wrong.

GIT Flashcard List

53 flashcards
1)
2)
3)
4)
5)
6)
7)
8)
9)
10)
11)
12)
13)
14)
15)
16)
17)
18)
19)
20)
21)
22)
23)
24)
25)
26)
27)
28)
29)
30)
31)
32)
33)
34)
35)
36)
37)
38)
39)
40)
41)
42)
43)
44)
45)
46)
47)
48)
49)
50)
51)
52)
53)