|A||Inhibit cholinergic smooth muscle stimulation in the gastrointestinal tract|
|B||Decrease lower esophageal sphincter pressure|
|C||Stimulate D2 receptor|
|D||Enhance colonic motility|
Metoclopramide is a D2 receptor antagonist that increases cholinergic activity by inhibiting pre-synpatic D1receptors in GIT (D, receptor stimulation inhibits the release of ACh).
• it increase LES tone that is also responsible for anti-emetic action.
• It does not significantly increase colonic motility.
• But out of the four options, this is the best answer, because although not significantly but it can increase colonic motility, whereas other options are definitely wrong.