Metyrapone is useful in testing endocrine function of which of the following? (AIIMS Nov 2009)
|A||α cells of pancreatic islets|
|B||β cells of pancreatic islets|
|C||Leydig’s cells of the testes|
a. Metyrapone, because it decreases serum levels of cortisol by inhibiting the 11-hydroxylation of steroids in the adrenal, can be used to assess function of the pituitary-adrenal cortical axis.
b. When metyrapone is given to normal persons, the adenohypophysis secretes more ACTH.