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Neurotransmitters In Mood Disorder

  1. Most accepted biochemical hypothesis for mood disorders is the monoamine hypothesis, according to which serotonin and norepinephrine are the major neurotransmitters involved in mood disorders: -
  2. Depression Decrease in serotonin and norepinephrine. Serotonin is the most important neurotransmitter in depression.
  3. Mania Increased level of norepinephrine
  4. Patients suffering from severe depression with suicidal intent/attempt appear to have a marked decrease in serotonin.
  5. Acetylcholine and GABA are the other neurotransmitters which are involved in mood disorders.
In depression, decreased REM latency & Increased duration of the first REM sleep & delayed sleep onset.

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