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Medicine

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Hematology

Question
6 out of 9
 

Most common inherited thrombotic disorder is :



A Protein C deficiency

B Protein S deficiency

C Factor V Leiden mutation

D Prothrombin gene mutation

E tPA deficiency

Ans. C

Factor V Leiden mutation

Factor V Leiden

1. M/C genetic cause of thrombosis

2. M/C congenital cause of venous thrombosis

3. M/C hereditary coagulable condition

Antiphospholipid syndrome (Hypercoagulability)

1. anti cardiolipin ab

2. Anti β-2 glycoprotein 1 ab

3. Lupus anticoagulant

4. Thrombocytopenia

5. Recurrent abortion

6. Pregnancy Induce Hypertension

7. Thrombotic effects in Artery & Vain

8. PTT 9. False +ve VDRL

Other’s causes of False +ve VDRL

1. Recent viral infection

2. Immunization

3. Genital herpes HIV

4. Malaria

5. Parental drugs use

6. old Ag

7. Rheumatoid arthritis

Table - Risk Factors for Venous Thrombosis (Ref. Hari-. 18th ed., Pg. 987, Table, 117.3)

Acquired

Inherited

Major surgery

Antithrombin deficiency

Major trauma

Protein C deficiency

PNH

Protein S deficiency

Malignancy

Factor V Leiden (FVL)

Antiphospholipid syndrome

Prothrombin

Puerperium, Pregnancy

Dysfibrinogenemia

Prolonged bed rest

Pregnancy Hyperhomocysteinemia

Obesity

Plaster cast

Hormonal replacement therapy

Myeloproliferative disorders

Long-haul travel

Old Age

Fibrinolytic drugs

Mechanism of Action (Ref. Hari- 18th ed., Pg. 981, Fig, 118.3)

Fig: The fibrinolytic system and its regulation. Plasminogen activators convert plasminogen to plasmin. Plasmin then degrades fibrin into soluble fibrin degradation products. The system is regulated at two levels. Type 1 plasminogen activator inhibitor (PAI-1) regulates the plasminogen activators, whereas α2-antiplasmin serves as the major inhibitor of plasmin.

The plasminogen – Plasmin System

Examples of fibrinolytic agents:- Streptokinase; acylated plasminogen streptokinase activator complex (anistreplase); urokinase; recombinant tissue-type plasminogen activator (rt-PA), which is also known as alteplase or activase; and two recombinant derivatives of rt-PA, tenecteplase and reteplase.

New Fibrinolytic Agents (Ref. Hari- 18th ed. Pg. 1003)

Desmoteplase, Alfimeprase

Hematology Flashcard List

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