Oncology and Fibroids
Most common serotype of HPV associated with invasive cervical carcinoma is (DNB, Nov. 2008)
1. HPV is associated with 80% of CIN and over 90% of invasive carcinoma
2. HPV -16 is most common HPV associated with squamous cell carcinoma. HPV -18 is most common HPV associated with Aden carcinoma.'
3. As it is well known that histologically 95% of cervical ca are SCC and only 5% adenoca. Hence HPV is the most common serotype of HPV associated with cervical ca.
4. On the basis of strength of association to cacervix, HPV has been classified into:
a. Low risk type-6, 11, 42, 43
Causes CIN and condyloma acuminate
b. Intermediate risk-33, 35, 55, 52
Causes CINI and CIN that don't progress.
c. High risk- 16, 18,31,39,45,56,48,59
Causes high grade CIN that progresses to invasive cA.