Most common site of urethral ca in males
a. Most common site of urethral tumor is membranous urethra followed by penile and prostatic urethra.
b. Most common type of primary urethral cancer is transitional cell carcinoma, followed by squamous and adenocarcinoma.
c. Once invasive cancer is detected, radical surgery is indicated though the prognosis is usually poor.
d. In females the most common site of tumor invasion are labia, vagina, and bladder neck.
e. In males , the most common site of extension are the vascular spaces of corpora or periurethral tissue, deep tissue of perineum, urogenital diaphragm, prostate, penile and scrotal skin where it causes abscess and fistulas.
f. Etiology is obscure HPV has been found to be associated with few cases.
a. Diminished stream, straining to void, and other obstructive voiding symptoms (Although these are often the symptoms of benign stricture disease, a neoplasm may be concealed by the presentation of a routine stricture.
b. Frequency, nocturia, itching, dysuria, and other irritative voiding symptoms (These are reported notoriously in association with carcinoma in situ.)
Surgery is indicated to confirm a diagnosis of clinically suspected urethral cancer.
More extensive surgery is indicated for local control of a primary urethral neoplasm and depends on the size, location, and extent of the tumor and the overall condition of the patient