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Pathology

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Miscellaneous

Question
24 out of 28
 

Most common skin malignancy mostly seen in sunexposed skin of fair person is (AIIMS May 2014)



A Basal cell carcinoma

B Dermatofibrosarcoma protuberans

C Merkel cell carcinoma

D Squamous cell carcinoma

Ans. D Squamous cell carcinoma

a. Squamous cell carcinomas (SCCs) are one of the most common malignancies of the skin.

b. They are usually found on sun-exposed skin of fair persons as a result of sun damage.

c. This exposure to ultraviolet radiation with DNA damage is the most common etiology of SCCs, as indicated by the precursor lesion to SCC, actinic keratosis; however, SCCs are also associated with other conditions such as immunosuppression or inherited defects in DNA repair (xeroderma pigmentosa). SCCs may also develop in an area of chronic scarring, such as an osteomyelitis sinus tract or an old burn scar.

d. An SCC arising in the latter is more likely to metastasize than an SCC occurring in sun-damaged skin.

e. Basal cell carcinomas are also typically found in sun-damaged skin and are also associated with immunosuppression and xeroderma pigmentosa.

f. Neither adnexal tumors nor Merkel cell carcinomas (a malignancy of small neural-crest-derived cells having neurosecretory cytoplasmic granules) are associated with old burn scars

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