Diseases & National Health Programme
Most diagnostic of rabies: (DNB June 09)
|B|| Gaurneiri bodies|
|D||H. P. bodies|
Negri bodies are intracytoplasmic inclusions seen in rabies affected nerve cells and their presence is pathognomonic of rabies. Some other methods of diagnosis of rabies are as follows:
A clinical diagnosis of hydrophobia can be made on the basis of history of bite by a rabid animal and characteristic signs and symptoms.
Rabies can be confirmed in patients early in the illness by antigen detection using immunofluorescence of skin biopsy, and by virus isolation from saliva and other secretions. Immunofluorescence of corneal impression smears has proved unreliable. Neutralising antibodies are not usually detectable in serum or CSF before the eighth day.