Most effective drug to treat brittle asthma (PNQ)
Recent Advances: Newer types of asthma (Ref. Hari-18th ed., Pg- 2114)
1). Some patients show chaotic variations in lung function despite taking appropriate therapy.
2). Some show a persistent pattern of variability and may require oral corticosteroids or, at times, continuous infusion of Beta2-agonists (type I brittle asthma).
3). Whereas others have generally normal or near-normal lung function but precipitous, unpredictable falls in lung function that may result in death (type 2 brittle asthma).
4). These latter patients are difficult to manage as they do not respond well to corticosteroids, and the worsening of asthma does not reverse well with inhaled bronchodilators.
5). The most effective therapy is subcutaneous epinephrine, which suggests that the worsening is likely to be a localized airway anaphylactic reaction with edema.
6). In some of these patients, there may be allergy to specific foods.