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Paediatric

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Malignancies

Question
19 out of 61
 

Most of the ALLs have- (AIPG 2012)



A B-cell origin
B T-cell origin

C NK cell origin
D None

Ans. A

B-cell origin

Acute lmphoblasticleukemir / lvmphoma

a. Acute lymphoblastic leukemia (AIL) encompasses a group of neoplasms composed of immature, precursor B

b. (Pre-B) or T (Pre-T) lymphoc)rtes referred to as lymphoblast

c. Majority (85%) of all ALLs are precursor B{ell tumors that tnically manifest as childhood .6leukemia" with

d. extensive bone marrow and variable peripheral blood involvement

e. The less common precursor T-cell ALLS tend to present in adolescent males as (lymphomas', often with thymic

f. involvement

g. Peak incidence of Pre B-cell ALL is evident between 3-5 yeers and ALL is the mo3t common childhood cancer,

h. Pre T-cell ALL occurs in adolescent male.

i. Morphology of tumor cell (lymphobtast)

i. Having scant cytoplasm and nuclei somewhat larger than those of small lyrnphocytes.

ii. The nuclear chromatin is delicate and finely stippled and nucleoli are either absent or inconspicuous.

iii. Contain cytoplasmic aggregates of Deriodicacidschiff (PAS) positive material.

Malignancies Flashcard List

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