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Biochemistry

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Enzymes

Question
3 out of 20
 

Mucopolysaccharide hyaluronic acid is present in:



A Aqueous humour
B Vitreous humor

C Lens
D Cornea

Ans. B Vitreous humor

Types of mucopolysaccharides

  1. Chondroitin 4/6 sulphate-cartilage, aorta, tendon, ligament *most abundant GAG (glycosamino­glycan) in body
  2. Keratansulphate-KS -cornea, KS -Loose connective tissue *most heterogenous GAG
  3. Hyaluronic acid-synovial fluid of joints, vitreous, umbilical cord, loose connective tissue, cartilage
  4. D/d from others-only GAG not limited to animal tissue; unsulfated; not covalently attached to protein
  5. Dermatansulphate-skin, blood vessels, heart valves
  6. Heparin-unlike other GAG is intracellular in most cells that line arteries, liver, lung, skin
  7. Heparansulphate-basement membrane, ubiquitous component of cell surface.

I Cell Disease

  1. Enzyme destined for lysosome is phosphorylated at one of the mannose residues (mannose-6-P)
  2. This disease is characterized by deficiency of ability to phosphorylate mannose
  3. Skeletal abnormalities, restricted joint movement, coarse facial features, psychomotor impairment.

Hyaluronic acid is non sulphatedmucopolysaccharide.

Enzymes Flashcard List

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