3 out of 20
Mucopolysaccharide hyaluronic acid is present in:
Ans. B Vitreous humor
Types of mucopolysaccharides
- Chondroitin 4/6 sulphate-cartilage, aorta, tendon, ligament *most abundant GAG (glycosaminoglycan) in body
- Keratansulphate-KS -cornea, KS -Loose connective tissue *most heterogenous GAG
- Hyaluronic acid-synovial fluid of joints, vitreous, umbilical cord, loose connective tissue, cartilage
- D/d from others-only GAG not limited to animal tissue; unsulfated; not covalently attached to protein
- Dermatansulphate-skin, blood vessels, heart valves
- Heparin-unlike other GAG is intracellular in most cells that line arteries, liver, lung, skin
- Heparansulphate-basement membrane, ubiquitous component of cell surface.
I Cell Disease
- Enzyme destined for lysosome is phosphorylated at one of the mannose residues (mannose-6-P)
- This disease is characterized by deficiency of ability to phosphorylate mannose
- Skeletal abnormalities, restricted joint movement, coarse facial features, psychomotor impairment.
Hyaluronic acid is non sulphatedmucopolysaccharide.