Multienzyme complex in humans
|A||Fatty acid synthetase|
|B||Malonyl CoA Carboxylase|
|C||Carbamoyl phosphate synthetase|
Fatty acid synthase complex
a. is a polypeptide containing seven enzymes activites = multienzyme complex
b. The complex is a dimer of two identical polypeptide monomers, each consisting of seven enzymes and Acyl carrier protein ACP * Head to tail arrangement of two monomers.
c. Enzymes are →Thio esterase, KetoacylReductase, Enoylreductase, Hydratase, Malonyltransacylase, Acetyl transacylase, Ketoacyl synthase.
i.Acetyl CoA carboxylase →is a MultienzymeProtein Rate limiting enzyme for fatty acid synthesis,
ii.Contain →biotin, biotin carboxylase, biotin carboxyl carrier protein, Transcarboxylase and a regulatory Allosteric site.
Carbamoyl phosphate synthetase→ rate limiting enzyme mitochondrial in urea synthesis