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Pathology

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Kidney

Question
5 out of 60
 

Multinucleated giant cells in kidney may be seen in: (LQ)



A Diabetic nephropathy
B Multiple myeloma

C Hypertensive nephropathy
D Acute tubular necrosis

Ans. B Multiple myeloma

When macrophages fail to deal with particle to be removed, they fuse together and form multinucleated giant cells

Giant cells

Associated disease

a. 1. Langhans giant cells

Tuberculosis and sarcoidosis

b. 2. Touton giant cells

Xanthoma

c. 3. Foreign body giant cells

Leprosy, TB, chronic infective granuloma.

d. 4. Tumour giant cells

Carcinoma of liver and various soft tissue tumour.

In multiple myeloma, myeloma nephrosis occurs in many cases. Renal involvement in multiple myeloma is k/a myeloma nephropathy. In distal convoluted tubular light chain protein (Bence Jones Protein) precipitate with combination of Tamm Horsfall protein as tubular cast, these tubular cast surround by some multinucleate giant cells.

Kidney Flashcard List

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