Neonatal thymectomy leads to:
|A||Decreased size of germinal centers of lymph nodes|
|B||Decreased size of paracortical areas of lymph nodes|
|C||Increased antibody production by B cells|
|D||Increased bone marrow production of lymphocytes|
The T cell containing, i.e thymus dependent areas – White pulp of the spleen and paracortical areas of lymph nodes.
Hence neonatal thymectomy will lead to Decreased size of paracortical areas of lymph nodes
· Absent Thymus / Aplastic thymus
· Thymic Hypoplasia (aplasia sometimes)
In Ataxia telangiectasia, DiGeorge syndrome
Seen in DiGeorge syndrome acquired by parathyroid developmental failure.
Also seen in SCID, (reticular dysgenesis also seen)
acquired T - in aged or in young due to malnutrition, post irradiation, steroid/cytotoxic T/t.
In MG mainly. also in Grave's disease, SLE, RA, scleroderma, cirrhosis of liver.
- MC primary tumor of anterior mediastinum
- associated with Myasthenia Gravis also with other paraneoplastic syndrome such as acquired hypogammaglobulinemia, pure red cell aplasia, Grave's disease, PA, dermatomyositis, Cushing syndrome.
a. In thymoma removal of tumor improves neuromuscular disorder.
b. Thymic hyperplasia in a young female is a good prognostic predictor.
Prognosis after thymectomy- better in
a. Younger patient benefit more from thymectomy than do those over age 40 year
b. Female benefit more
c. Good in-patient with shorter duration of disease, early stage of thymoma.
d. Absence of thymoma
e. Associated MG or thymic hyperplasia