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Paraneoplastic Syndromes

Syndrome                        

Associated tumours

Retinal degeneration

Small –cell carcinoma of lung

Opsoclonus myoclonus

Ovarian, lung

Neuroblastoma (in children)

Sensory neuropathy

Small-cell carcinoma of lung

Hodgkin’s disease

Limbic encephalitis

Small-cell carcinoma of lung, Hodgkin’s disease

Myelitis

Small-cell carcinoma of lung

Cerebellar degeneration

Small – cell carcinoma of lung, Ovarian, Breast

Hodgkin’s disease

Subacute motor neuronopathy

Hodgkin’s disease, Small – cell carcinoma of lung

Sensorimotor peripheral neuropathy

Small – cell carcinoma of lung, Breast

Other carcinoma

Lambert – Eaton myasthenic syndrome

Small-cell carcinoma of lung

Dermatomyositis / Polymyositis

Lung, breast, ovary

Guillain – Barre

Hodgkin’s disease


Paraneoplastic Antineuronal Antibodies

 

Table 97-2 Paraneoplastic Antineuronal Antibodies, Associated Syndromes and Cancers (Ref. Hari. 18th ed., page - 624)

Antibody

Syndrome

Associated Cancers

Anti-Hu

PEM (including cortical, limbic, brainstem encephalitis, cerebellar dysfunction, myelitis), PSN, autonomic dysfunction

SCLC, other neuroendocrine tumors

Anti-Yo

PCD

Ovary and other gynecologic cancers, breast

Anti-Ri

PCD, brainstem encephalitis, opsoclonus-myoclonus

Breast, gynecological, SCLC

Anti-Tr

PCD

Hodgkin's lymphoma

Anti-Zic

PCD, encephalomyelitis

SCLC and other neuroendocrine tumors

Anti-CV2/CRMP5

PEM, PCD, chorea, peripheral neuropathy, uveitis

SCLC, thymoma, other

Anti-Ma proteinsa
 

Limbic, hypothalamic, brainstem encephalitis (infrequently PCD)

Germ-cell tumors of testis, lung cancer, other solid tumors

Anti-NR1/NR2 subunits of NMDA receptor

Encephalitis with prominent psychiatric symptoms, seizures, hypoventilation

Ovarian teratoma

Anti-amphiphysin

Stiff-person syndrome, PEM

Breast, SCLC

Anti-VGCCb

LEMS, PCD

SCLC, lymphoma

Anti-AChRb

MG

Thymoma

Anti-VGKCb

Peripheral nerve hyperexcitability (neuromyotonia), limbic encephalitis

Thymoma, SCLC, others

Anti-recoverin

Cancer-associated retinopathy (CAR)

SCLC and other

Anti-bipolar cells of the retina

Melanoma-associated retinopathy (MAR)

Melanoma


aPatients with antibodies to Ma2 are usually men with testicular cancer. Patients with additional antibodies to other Ma proteins are men or women with a variety of solid tumors.

 

bThese antibodies can occur with or without a cancer association.





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