Nitroglycerin causes all except (AIIMS Nov 2009)
|A||Hypotension and bradycardia|
|C||Hypotension and tachycardia|
a. Nitrates are most commonly used antianginal drugs. These act by delivering nitric oxide in the blood vessels leading to vasodilation. As per Merry’s law, hypotension is followed by tachycardia and not bradycardia.
b. Constipation and gastro-esophageal reflux disease is a common problem in patients taking nitrates. Nitrates act by relaxing the smooth muscles. The control of smooth muscles is shown in the following figure (BG Katzung: Basic & Clinical Pharmacology, 10th Ed’ 2007, pp 265).