65 out of 71
Not true about thalidomide(LQ)
|B||Not tested in pregnant animals before introduction|
|C||Still has restricted clinical use|
|D||Has no antiagiogenesis action against tumor|
Ans. D Has no antiangiogenesis action against tumor (Ref. ; KDT's 6th/84, 834)
- Thalidomide was banned in 1960 because of its teratogenic effect of phocomelia (seal like limbs).
- It has anxiolytic, adjuvant analgesic/ antipyretic properties and has been found to counteract cancer associated cachexia.
- Its mechanism of action is by suppressing TNF and or by modulating IL-2.
- Recently it has been reintroduced as antineoplastic drug due to its anti-angiogenesis action.