Vocal cords paralysis
Of the following statements about Recurrent Laryngeal papillomatosis are true, Except
|A||Caused by Human Papilloma Virus (HPV)|
|B||HPV6 and HPV11 are most commonly implicated|
|C||HPV6 is more virulent than HPV11|
|D||Transmission to neonate occurs through contact with mother during vaginal delivery|
Nelson's pediatrics 7 8thl7 772; Current Otorhinology 2ndled pg-4351477 'Pediatric ENT' by Graham. Scadding and Bull (2008) 1258
Recurrent Laryngeal Papillomatosis I Recurrent Respiratory Papillomatosis
• Associated with Human Papilloma Virus infection (HPV)
• HPV6 and HPV 11 are most commonly associated with laryngeal disease whereas HPV 16 and HPV 18 are less commonly associated.
• HPV11 is associated with a more aggressive disease and makes the patient more prone to malignant change
• Thus HPV 11 is more virulent
• Most commonly occur in children <5 years of age (2 -5 years)
• Male female ratio - same (first born vaginally delivered child of a teenage mother is most prone)
• Exact mode of transmission is not known.
• There is recognized transmission from genital warts.
• Vertical transmission of virus from mother to child can occur either as ascending uterine infection or through direct contact in birth canal.
Malignant transformation in a case of papilloma occurs most commonly in distal bronchopulmonary tree and prognosis is univer¬sally poor