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Pharmacology

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GIT

Question
23 out of 53
 

On your way to an examination you experience that vulnerable feeling that an attack of diarrhea is imminent. If you stopped at a drugstore, you could buy this antidiarrheal drug without a prescription even though it is related chemically to the strong opioid-analgesic meperidine (AIPG 2009)



A Aluminum hydroxide
B Diphenoxylate

C Loperamide
D Magnesium hydroxide

E Metoclopramide

Ans. C Loperamide

a. Aluminum hydroxide is constipating but is not related chemically to meperidine; magnesium hydroxide is a strong laxative.

b. The two antidiarrheal drugs that are structurally related to opioids are diphenoxylate and loperamide.

c. Loperamide is available over-the-counter; diphenoxylate is mixed with atropine alkaloids, and the product (Lomotil, others) requires a prescription.

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