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Most Common Malignancy

  1. Overall – CA lung
  2. In males
    1. Globally – CA prostate
    2. In developing world – CA lung
  3. In females
    1. Globally – CA breast
    2. In developing world – CA cervix
Hereditary neoplasms Inheritance
Retinoblastoma
Familial adenomatous polyposis coli ……………… AD
Multi endocrine neoplasia I ……………… AD
Multiple endocrine neoplasia II ……………… AD
Neurofibromatosis type I (von Recklinghausen’s ds). ……………… AD
Wilm’s tumor ……………… AD
Li Fraumeni syndrome ……………… AD
  
Hereditary preneoplastic conditions:
 
(i) Defective DNA repair:
Xeroderma pigmentosum AR
Bloom’s syndrome AR
Fanconi’s anemia AR
Ataxia-telangiectasia AR
(ii) Immune deficiency syndromes:
X-linked agammaglobulinemia XR
Woskott – Aldrich syndrome XR




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