Osteogenesis imperfecta is a heritable bone disorder, it is a heterogenous condition and there are a latest 4 subgroups showing variations in phenotype and pattern of inheritance. All the following are common features of the various subtypes except:
|B||Proneness to fracture|
|C||Laxity of ligaments|
|D||Very high mortality|
Very high mortality
Osteogenesis imperfecta is a heritable disorder in which, there is defective synthesis of collagen type I. There are at least 4 Subgroups showing variations in phenotype pattern of inheritance as described by silence, of which only type II is lethal.