Osteosarcoma, used all except (DNB Dec 2011)
|A||High dose methotrexate|
|D||Bleomycin, Etoposide, Doxorubicin|
a. Though, surgery is the form of primary treatment in osteosarcoma but etoposide, cyclophosphamide, isplatin and doxorubicin have been usea. High dose methotrextae has been the drug of choice and is the only FDA approved agent for this condition.
b. Cyclophophamide is most commonly used alkylating agent and has long been the drug of choice for Wegner’s Granulomatosis and is also used for non-Hodgkin lymphoma, neuroblastoma and cancer of ovaries. Most common side effect of drug if hemorrhagic necrosis of urinary bladder which is mediated by a toxic metabolite named acrolein.
c. Bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) regimen given in 14-day intervals (BEACOPP-14) with granulocyte colony-stimulating factor (G-CSF) support is used in advanced Hodgkin's lymphomA. Vincristine is a rapidly acting Vinca alkaloid and is used in treatment of leukemia and lymphomas.
d. The drug produces peripheral neuropathy and syndrome of inappropriate secretion as side effect (BG Katzung’ 10th Edition, pp-891)..