Paclitaxel acts by (DNB June 2012)
|B||Inhibition of Microtubule formation|
|C||Mitotic cell inhibitor|
|D||Exaggerates polymerization and causes the stabilization of the microtubules|
a. It is a complex diterpine taxane obtained from bark of the Western yew tree, which exerts cytotoxic action by a novel mechanism.
b. It enhances polymerization of tubulin: a mechanism opposite to that of vinca alkaloids.
c. The microtubules are stabilized and their depolymerization is prevented.
d. This stability results in inhibition of normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic functions.
e. Abnormal arrays or ‘bundles’ of microtubules are produced throughout the cell cycle.
f. Cytotoxic action of paclitaxel emphasizes the importance of tubulin microtubule dynamic equilibrium.
g. The approved indications of paclitaxel are metastatic ovarian and breast carcinoma after failure of first line chemotherapy and relapse cases.
h. It has also shown efficacy in advanced cases of head and neck cancer, small cell lung cancer, esophageal adenocarcinoma and hormone refractory prostate cancer.