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Orthopaedic

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Metabolic Bone Diseases

Question
38 out of 42
 

Paget's disease of bone (PGI Nov 2011)



A May present with neurological complications or a pathological fracture

B Causes an increase in both serum calcium and phosphate

C Causes an increase in serum alkaline phosphatase

D Malignant change occurs in 1% of patients

E The commonest malignant tumour in patients with Paget's disease is a chondrosarcoma

Ans. A

May present with neurological complications or a pathological fracture

C. Causes an increase in serum alkaline phosphatase

D. Malignant change occurs in 1% of patients

a. Paget's disease was first described as 'osteitis deformans' by Sir James Paget in 1877.

b. It is often asymptomatic and an incidental finding seen during radiological investigations. If symptomatic it presents with bone pain, neurological symptoms or a pathological fracture.

c. In those patients who develop malignant change 50% are osteosarcomas, 25% fibrosarcomas and 25% giant-cell tumours. The median survival following malignant change is less than one year.

Metabolic Bone Diseases Flashcard List

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