Central Nervous System
Part of brain most sensitive to hypoxia is?
- This occurs from lack of delivery of 02 (=Hypoxia) to the brain because of hypotension or respiratory failure
- Pathologic findings
a. Principal histological findings are extensive multifocal or diffuse laminar cortical necrosis, with almost invariable involvement of the hippocampus.
- "The hippocampal CA1 neurons are vulnerable to even brief episodes of hypoxia (ischemia) Q, perhaps explaining why selective persistent memory deficits may occur after brief cardiac arrest".
IV. Scattered small areas of infarction or neuronal loss may be present in the basal ganglia, hypothalamus
V. or brainstem.
- In some cases, extensive bilateral thalamic scarring may affect pathways that mediate arousal.