Pathergy test is done for? (AIPG 07)
Clinical Features-Diagnostic Criteria of Beh|et’s Disease = One Major & Two minor criteria’s.
Major criteria -Recurrent oral ulceration
Minor Criteria -
1. Recurrent genital ulceration
2. Eye lesions (Ant and post uveitis) can progress rapidly to blindness.
3. Skin lesions (Erythema nodosum, Pseudofolliculitis)
4. Pathergy test (Nonspecific skin inflammatory reactivity to any scratches or intradermal saline injection
Other features are:
ii. Superficial thrombophlebitis
iii. Arthritis – Nondeforming, mainly involve knees and ankle.
Iv. CNS involvement – mainly in the parenchymal has a serious prognosis (CNS – Beh|et’s syndrome)
1. Myocarditis is not a feature.
2. In Beh|et syndrome there is Panuveitis i.e. there is involvement of both anterior & posterior uvea.
Pathogenesis (Ref: H-18th edition, Pg-2801)
Circulating autoantibodies against -enolase of endothelial cells and anti–Saccharomyces cerevisiae antibodies (ASCA—characteristic of Crohn's disease) are found to be present in the later stages of the disease.