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Pathology

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CVS

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Pathological changes seen in malignant hypertension are termed as ? (AIIMS May 2013)



A Medial calcific sclerosis

B Arteriosclerosis obliterans

C Hyperplastic arteriolosclerosis

D Hyaline arteriolosclerosis

Ans. C Hyperplastic arteriolosclerosis

a. Malignant hypertension refers to dramatic elevations in systolic and diastolic blood pressure often resulting in early death from cerebral and brainstem hemorrhages.

b. Pathologically, the renal vessels demonstrate a concentric obliteration of arterioles by an increase in smooth-muscle cells and protein deposition in a laminar configuration that includes fibrin material, which leads to total and subtotal occlusion of the vessels.

c. These changes are called hyperplastic arteriolosclerosis. In contrast, hyaline arteriolosclerosis as seen in diabetes mellitus is presumably caused by leakage of plasma components across the endothelium with or without hypertension.

d. Medial calcific sclerosis (Monckebergs arteriosclerosis) is characterized by dystrophic calcification in the tunica media of muscular arteries.

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