Coupon Accepted Successfully!


Gianotti–Crosti Syndrome

  1. Infantile popular acrodermatitis, or the Gianotti-Crosti syndrome, presents with symmetric erythematous lichenoid papules on the face, extremities, and buttocks, usually sparing the trunk
  2. The eruption is not pruritic and may be accompanied by Splenomegaly, hepatitis, and lymphadenopathy
  3. The process often occurs in young children after an upper respiratory tract illness
  4. Pathologic specimens show a perivascular infiltration of lymphocytes and histiocytes in the upper portion of the dermis
  5. While the syndrome has been associated with hepatitis B and enterovirus infection, several cases have been associated with acute EBV infection
  1. Henoch Schönlein purpura Triad of
    a. Purpura       b. Arthralgia     c. Abdominal pain.
    1. Henoch Schönlein purpura is a IgA mediated vasculitis syndrome affecting skin, joints, GIT and kidneys
    2. It usually occurs below the age of 20 years
    3. The eruption may begin as crops of palpable purpuric lesions or urticarial rash in the lower legs and buttock
    4. Abdominal symptoms such as colic, vomiting and diarrhea are seen in two-third of the patients
    5. Polyarthralgia is seen in most patient and renal involvement can rarely lead to chronic nephritis
    6. Diagnosis: Histopathology shows leukocytoclastic vasculitis and immunofluorescence demonstrates IgA deposition around blood vessels
    7. Treatment: No specific treatment available. Antibiotics and corticosteroids can be given to alleviate symptoms
  2. Urticaria pigmentosa
Urticaria pigmentosa is the most common type of cutaneous mastocytosis that occurs due to the accumulation of mast cells in the skin
  1. The skin lesions are itchy small, yellow tan to reddish brown macules scattered all over the body
  2. Mild trauma such as scratching or rubbing the lesions may cause urtication and erythema around macules this is know nas Darier’s sign
  3. Urticaria pigmentosa is associated with Pruritus which may be exacerbated by temperature, friction, spicy food, alcohol and drugs
  4. Diagnosis: Histopathology shows mast cell infiltration in the dermis
  5. Treatment: Avoidance of precipitating factors and antihistaminics

Test Your Skills Now!
Take a Quiz now
Reviewer Name