Pellagra is caused by deficiency of:
Niacin is also known as nicotinic acid / niacinamide / nicotinamide / pellagra preventing factor. Niacin is the generic term for nicotinic acid (pyridine-3-carboxylic acid) and derivatives that exhibit the nutritional activity of nicotinic acid. In one sense, niacin is not a vitamin, since it can be formed from the essential amino acid tryptophan. Niacin is essential for the metabolism of carbohydrate, fat and protein. Foods rich in niacin and or tryptophan are liver, kidney, meat, poultry, fish, legumes and groundnut. Milk is a poor source of niacin but its proteins are rich in tryptophan which is converted in the body into niacin. An average of about 1 mg of niacin is formed from 60 mg of dietary tryptophan. Accordingly, estimates of the adequacy of dietary intake must take into account the content of both tryptophan and niacin. Pellagra occurs due to deficiency in the diet or failure of the body to absorb niacin (nicotinic acid) or its amide (niacinamide, nicotinamide). Usually it is associated with a deficiency of tryptophan containing proteins. Pellagra is a wasting disease due to deficiency of nicotinic acid, characterized by dementia, diarrhea, dermatitis, glossitis and stomatitis.