Loading....
Coupon Accepted Successfully!

Medicine

Open Flashcards

Hematology

Question
19 out of 34
 

Peripheral smear with increased neutrophils, basophils, eosinophils, and platelets is highly suggestive of



A Acute myeloid leukemia

B Acute lymphoblastic leukemia

C Chronic myelogenous leukemia

D Myelodysplastic syndrome

Ans. C

Chronic myelogenous leukemia

Accelerated phase

The WHO criteria to define the accelerated phase by any of the following:

1. 10–19% myeloblasts in the blood or bone marrow

2. >20% basophils in the blood or bone marrow

3. Platelet count <100,000, unrelated to therapy

4. Platelet count >1,000,000, unresponsive to therapy

5. Cytogenetic evolution with new abnormalities in addition to the Philadelphia chromosome

6. Increasing splenomegaly or white blood cell count, unresponsive to therapy

The patient is considered to be in the accelerated phase if any of the above are present. The accelerated phase is significant because it signals that the disease is progressing and transformation to blast crisis is imminent.

Blast crisis

Blast crisis is the final phase in the evolution of CML, and behaves like an acute leukemia, with rapid progression and short survival. Blast crisis is diagnosed if any of the following are present in a patient with CML:

1. >20% myeloblasts or lymphoblasts in the blood or bone marrow

2. Large clusters of blasts in the bone marrow on biopsy

3. Development of a chloroma (solid focus of leukemia outside the bone marrow)

Hematology Flashcard List

34 flashcards
1)
2)
3)
4)
5)
6)
7)
8)
9)
10)
11)
12)
13)
14)
15)
16)
17)
18)
19)
20)
21)
22)
23)
24)
25)
26)
27)
28)
29)
30)
31)
32)
33)
34)