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Pathology

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Neoplasia

Question
12 out of 24
 

Philadelphia chromosome occurs due to reciprocal translocation of: (AIIMS May 2014)



A 9 and 22 chromosomes
B 15 and 17 chromosomes

C 3 and 21 chromosomes
D 9 and 21 chromosomes

Ans. A 9 and 22 chromosomes

Important Tumour - suppressor genes and Associated Human Tumours

Gene

Location

Associated human tumours

1. APC

Cytosol

Familial APC (Adenomatous polyposis col)

2. Rb

Nucleus

Retinoblastoma

Osteosarcoma

3. NF 1

Plasma membrane

Neurofibromatosis type 1

4. BRCA 1, BRCA 2

Nucleus

Carcinoma ovary, carcinoma breast

5. p53

Nucleus (p17)

Colorectal cancer

6. WT 1

Nucleus

Wilm's tumour

Neoplasia Flashcard List

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