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Medicine

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Liver & GIT

Question
5 out of 8
 

Poor Response to antiviral therapy (IFN + Ribavirin) in hepatitis C is indicated by all except?



A High HCV-RNA
B Cirrhosis

C Age> 40 years
D Female sex

Ans. D Female sex

Factors associated with reduced responsiveness.

i. Geno type I

ii. High level HCV RNA (>2 million copies/ml or >8,00,000 IU/ml)

iii. Advanced fibrosis (bridging fibrosis, cirrhosis)

iv. Long duration disease

v. Age >40 years

vi. High HCV quasispecies diversity

vii. Male gender

viii. Immuno suppression

ix. Reduced adherence

x. Obesity

xi. Hepatic steatosis