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Medicine

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Endocrine

Question
9 out of 18
 

Pre tibial myxedema occurs in? (LQ)



A Hypothyroid
B Hyperthyroidism

C Hashimoto
D Graves’ disease

Ans. D

Graves’ disease

This is an autoimmune disease caused by stimulatory TSH-receptor antibodies (which also react with orbital autoantigens.)

These patient have HLA – B8, DR 3

TSH-receptor antibodies include

1). TSI (Thyroid stimulating Ig)

2). TGI (Thyroid growth stimulating Ig

3). TBII = TSH binding inhibitor Ig. It can stimulate or inhibit thyroid cell function

Extra Edge: It is associated with other autoimmune diseases: vitiligo, Type 1 DM, Addison's disease.

Grave disease is a triad of

1). Hyperthyroidism

2). Ophthalmopathy

3). Dermopathy

Extra Edge:

1). (Pre tibial myxedema occurs in dermopathy of Grave disease) !!!!.

2). Ophthalmopathy & Dermopathy occur only in Grave disease. They do not occur in any other cause of hyperthyroidism.

3). Grave disease is a type of hyperthyroidism but all hyperthyroid are not Grave Disease !!

Endocrine Flashcard List

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