Premenstrual syndrome is treated with (AIPG 2008)
1. Drugs like Fluoxetine are used along with Vit E and evening primrose oil.
2. The SSRIs fluoxetine and sertraline have been shown to be effective; other agents in this class presumably would work but are not as well studied.
3. Although use of SSRIs can be limited to the luteal phase (10–14 days), that approach is impractical for many patients, who may have difficulty determining when to start the drug. Hence it is simpler for the patients to simply take the medication every day.
4. Sertraline has a shorter half-life than fluoxetine.
5. The advantage of a shorter half-life is that if the patient experiences unacceptable side effects, the side effects will fade more rapidly once the medication is discontinued.
6. The most prominent side effect of SSRIs in patients with PMS/PMDD is sexual dysfunction.