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Pharmacology

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CNS Part- 2

Question
25 out of 42
 

Prompt administration of antipyretics, IV hydration, and bromocriptine or dantrolene, is necessary to combat a relatively rare but potentially fatal adverse response that is characteristically associated with which of the following?



A Benzodiazepines. Especially those used as hypnotic

B Chlorpromazine

C Levodopa

D Phenytoin

Ans. B Chlorpromazine

a. The question described common and necessary interventions for managing neuroleptic malignant syndrome, which is characteristically associated with older antipsychotics—chlorpromazine and other “low potency” antipsychotics to a degree, but occurs more so with haloperidol (butyrophe none).

b. Signs and symptoms include muscle tetany/rigidity (“lead pipe rigidity”), profound fever, rapid swings of heart rate, rhythm, blood pressure (autonomic instability), electrolyte abnormalities and dehydration. None of the other agents are associated with this syndrome, whether acutely or with long-term therapy or at therapeutic or toxic serum levels.

CNS Part- 2 Flashcard List

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