Pyoderma gangrenosum is seen in: (AIPG 2011)
1). Pyoderma gangrenosum is a rare but serious ulcerative disorder, which is often due to a serious underlying systemic Cdisease.
2). An acutely inflamed purple nodule develops, which rapidly becomes an ulcer.
3). This ulcer spreads with a frightening speed.
4). The ulcers may become 'dinner plate' sized or even larger.
5). Finally they become static and may then spontaneously heal.
6). A few patients have multiple lesions and may succumb to the disorder. Lesions may reoccur after a dormant phase.
7). The disorder may occur in the course of ulcerative colitis, Crohn's disease, rheumatoid arthritis or myeloma, although in about 50% of cases no predisposing cause if found.
8). It has been suggested that the tissue destruction is due to vasculitis.
9). DOC is systemic corticosteroid.
10). Cyclosporine, minocycline and dapsone have also been reported as promoting the healing of these lesions.