FILOVIRIDAE-BSL IV pathogens
- Long filamentous virus 80nmx 1000nm, enveloped, single stranded, negative sense RNA
- Marburg virus and Ebola virus- antigenically different from each other
- 4 subtypes of Ebola v- Zaire, Sudan, Reston, Ivory Coast.
- Pathogenesis- Transmitted to man from primates by aerosols, direct contact with blood, body fluids etc.
- Highly virulent infection, invariably fatal. Secondary spread between humans occurs
- Clinical features
I.P.: 3-15 days, patient develops headache, fever, myalgia, severe haemorrhages, hypotension
- Laboratory diagnosis
- Demonstration of virus: Electron microscopy
- Serology: Immunofluorescence