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PRIONS- lack nucleic acids
  1. Proteinaceous infectious particles
  2. Highly resistant to proteases, heat, radiation
  3. Can be inactivated by NaOH, Sodium hypochlorite 25%, phenol 90% 
    1. Diagnosis: Biopsy of brain tissue: spongiform encephalopathy
    2. Diseases of humans
      i. Kuru, Creutzfeldt-Jacob disease, Gerstmann-Straussler-Scheinker syndrome, Familial fatal insomnia
    3. Diseases of animals
      Scrapie of sheep & goats, Bovine spongiform encephalopathy of cattle, Mink & feline encephalopathy, Wasting disease of deer & elk

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