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Reoviridae
  1. Spherical virions, nonenveloped, segmented (10-12 segments), positive stranded ds DNA
  2. Medically important genera
  3. Orthoreovirus: 10 segments
  4. Orbivirus: 10 segments
  5. Rotavirus: 11 segments
  6. Coltivirus: 12 segments
  1. COLTIVIRUS: 2 serotypes, Causes Colorado tick fever, Transmitted by ticks
     
    I.P.: 3-6 days; myalgia, headache, leukopenia, rash
     
    Complications: meningoencephalitis, haemorrhagic fever
  2. ORBIVIRUS:  100 serotypes, Infections in animals; mild fevers in humans
  3. ORTHREOVIRUS:  3 serotypes, May be associated with enteritis in infants and children; upper respiratory tract infections, neonatal biliary atresia
  4. ROTAVIRUS: Divided into six groups (A-F) and 14 serotypes (9 human, 5 animal)
    1. Commonest cause of gastroenteritis in children below 2 years of age
    2. Infection is transmitted by contaminated water and food
    3. I.P.: 1-2days, vomiting , diarrhoea, dehydration
Laboratory diagnosis
  1. Antigen detection: latex agglutinaion, passive haemagglutination, ELISA
  2. Detection of virus: electron microscopy, immunoelectron microscopy
Viruses associated with acute gasteroenteritis in hiumans
Rota virus
Group A
 
 
Group B
 
Group C
 
Single most important cause (viral or bacterial) of endemic severe diarrheal illness in infants and young children worldwide
Outbreaks of diarrheal illness in adults and children in china
Outbreaks of diarrheal illness in children
Enteric adenoviruses Second most important viral agent of endemic diarrheal illness in infants and young children worldwide
Norwalk virus & Norwalk like viruses
27nm, single stranded RNA, positive sense, non enveloped
Important cause of outbreaks of vomiting and diarrheal illness in older children and adults in families, communities, institutions; frequently associated with ingestion of food
Caliciviruses
27-38nm, single stranded RNA, positive sense, non enveloped
Sporadic cases and outbreaks of diarrheal illness in infants, young children & adults
Astroviruses
30nm, nonenvelped, RNA viruses
Sporadic cases and outbreaks of diarrheal illness in infants, young children & adults
 




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